Winnonlin modeling2/13/2023 Dissolution rate constants, absorption rate constants or extent of absorption may be among the parameters to be estimated (example diagrams).Ĭonsideration of the data plotted on linear and semi-log graph paper will provide more information about a suitable model. The structure of this part of the model may be derived from an understanding of the dosage form and prior knowledge however certain parameter values may need to be determined by nonlinear regression. The extravascular routes may include multiple steps such dissolution and absorption in the case of oral administration or diffusion from a patch and through the skin in the case of a topical dose. Drug may be given by IV bolus injection, IV infusion, or an extravascular route such as oral, topical or inhalation. This might be single or multiple dose regimens. (Designing the experiment and planning the samples involves identifiability and optimal sampling, here we are concerned with modeling data already collected).įrom the route of administration the modeler can include details in the model that describe the administration. The two factors which need to be considered are the route of drug administration and the data that has been collected. The first step in the running a nonlinear regression problem is to visualize the model. Program Set-Up - General approach Model Visualization Chapter 8.2 - Program Set-Up - General Boomer Manual and Download
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